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Linezolid-DataSheet-MedChemExpress

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Product Data?Sheet
Linezolid
Cat. No.: CAS No.: Molecular Formula: Molecular Weight: Target: Pathway: Storage: HY-10394 165800-03-3 C??H??FN?O? 337.35 Bacterial Anti-infection 4°C, protect from light

Inhibitors ? Agonists ? Screening Libraries

Solvent & Solubility
In Vitro 10 mM in DMSO Mass 1 mg 5 mg 10 mg

Solvent Concentration Preparing Stock Solutions 5 mM 10 mM 1 mM

2.9643 mL 0.5929 mL 0.2964 mL

14.8214 mL 2.9643 mL 1.4821 mL

29.6428 mL 5.9286 mL 2.9643 mL

Please refer to the solubility information to select the appropriate solvent.

BIOLOGICAL ACTIVITY
Description Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. IC50 value:Target: AntibioticA member of the oxazolidinone class of drugs, linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycinresistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA).

CUSTOMER VALIDATION
????Drug Des Devel Ther. 2018 Jun 11;12:1679-1684. See more customer validations on www.MedChemExpress.com

REFERENCES

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[1].?Clemett D, Markham A. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828. [2].?Chiappini E, Conti C, Galli L et al. Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic review. Clin Ther. 2010 Jan;32(1):66-88. [3].?Perry CM, Jarvis B. Linezolid: a review of its use in the management of serious gram-positive infections. Drugs. 2001;61(4):525-51. [4].?He MZ, Jiang YW, Cai C.Mechanisms and epidemiology of linezolid resistance in staphylococci.Zhonghua Jie He He Hu Xi Za Zhi. 2012 May;35(5):360-2. [5].?Karau MJ, Tilahun AY, Schmidt SM, Clark CR, Patel R, Rajagopalan G.Linezolid is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA class II Transgenic Mice.Antimicrob Agents Chemother. 2012 Jul 30.

Caution: Product has not been fully validated for medical applications. For research use only. Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@MedChemExpress.com

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